Patents

Lasmiditan is expected to enjoy more than 10 years of commercial exclusivity after launch via patent coverage and NCE data exclusivity.

CoLucid owns or has exclusive rights to a significant worldwide patent portfolio covering both the 5-HT1F Receptor Agonists and the Conjugated Stigmines. Please see the attached list for a representative sampling of published applications and issued patents in the CoLucid portfolio.

5-HT1F Receptor Agonists
U.S. Patent No. 7,423,050 "Pyridinoylpiperidines as 5-HT1F Agonists" Download
WO 2010/115125 "Composition of 2,4,6-Trifluoro-N-[6-(-1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamide" Download
Conjugated Stigmines
U.S. Patent No. 7,897,639 "Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents" Download
U.S. Patent No. 7,795,307 "Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents" Download
WO 2008/097546 "Compounds that inhibit cholinesterase" Download
WO 2009/011901 "Methods for promoting wakefulness" Download
WO 2010/009316 "Stigmine Conjugates for Substance Abuse Disorders" Download
WO 2010/115124 "Compositions of Cholinesterase Inhibitors" Download

Lasmiditan

image of lasmiditan structure

Lasmiditan is a member of a novel chemical class called "ditans." Lasmiditan penetrates the central nervous system (CNS) and selectively targets 5-HT1F receptors expressed in the trigeminal nerve pathway.

Learn More About Lasmiditan


About Migraines

Approximately 30 million Americans have migraines (13% of adult population)

  • 18% of women and 6% of men experience migraines
  • Most common in working population from 25 to 55 years old
  • Direct medical expenditures exceed $11 billion per year in U.S.